20 Best Regional Sandwich Chains You Need To Try at Least Once

Sandwiches are a staple in American cuisine, offering a convenient and delicious meal option. Across the regions of the United States, several sandwich chains have gained iconic status for their unique offerings and loyal customer base. This blog post explores 20 of the best regional sandwich chains that you need to try at least once. Each offers a distinct culinary experience that reflects the local flavor and culture. From grocery store subs to gas station hoagies, these sandwich chains are beloved for their quality ingredients and innovative combinations.

1. Publix Subs

Lovingly called “Pub Subs,” these sandwiches are shockingly good. Fresh bread, Boar’s Head meats, and serious sandwich-making pride define this Florida and Southeast staple. Customers line up for these grocery store gems, appreciating the fresh ingredients and generous portions. Whether you prefer a classic turkey and cheese or something more adventurous, Publix offers something for everyone. Their dedication to quality and customer satisfaction sets them apart in the crowded sandwich market. Publix has become a beloved institution for sandwich enthusiasts in the region.

2. Jersey Mike’s

Not just regional anymore, Jersey Mike’s holds strong Jersey roots. Meats are sliced fresh to order and topped “Mike’s Way” with oil, vinegar, and spices. This attention to detail and authenticity has made Jersey Mike’s a favorite nationwide. Their commitment to quality ingredients and traditional preparation methods resonates with sandwich lovers. The chain’s expansion hasn’t diluted the original Jersey charm that first captured customers’ hearts. Whether you’re a local or a newcomer, Jersey Mike’s offers a taste of New Jersey in every bite.

3. Wawa

Is it a gas station? Yes. Sandwich royalty? Also yes. Wawa’s hot and cold hoagies, made fresh with tons of customization, have earned a cult following in PA, NJ, and beyond. Loyal fans appreciate the convenience and quality of Wawa’s offerings. The touch-screen ordering system adds a modern twist to traditional sandwich-making. Whether you’re grabbing a quick lunch or a late-night snack, Wawa delivers deliciousness. The chain’s unique blend of convenience store and deli has made it a beloved stop for travelers and locals alike.

4. Sheetz

Wawa’s rival, Sheetz, offers a grittier vibe with its touchscreen-order sandwiches. This Mid-Atlantic and Appalachian favorite is comfort food gold, especially after midnight. Known for its hearty and satisfying options, Sheetz appeals to night owls and road-trippers alike. The convenience and variety of their menu have made Sheetz a popular stop. Whether you’re craving a classic sub or something more adventurous, Sheetz delivers with flavor and flair. It’s a go-to destination for those seeking a quick and tasty meal on the road.

5. Langer’s Delicatessen

In LA, Langer’s Delicatessen is an institution. The #19 sandwich, with hot pastrami, Swiss, coleslaw, and Russian dressing, is a must-try. This West Coast legend offers more than just food; it’s a culinary experience. The rich flavors and classic preparation make each bite memorable. Langer’s dedication to quality and tradition keeps customers returning. Whether you’re a pastrami aficionado or a curious newcomer, Langer’s provides a taste of Los Angeles history. It’s a destination for anyone seeking an authentic deli experience.

6. Zingerman’s Deli

Zingerman’s Deli in Ann Arbor, MI, is a Midwestern legend. Known for its huge sandwiches made with artisan breads, house-made spreads, and high-quality meats and cheeses, it’s a destination for food lovers. The attention to detail and commitment to quality set Zingerman’s apart. Each sandwich is a masterpiece, crafted with care and precision. The deli’s reputation for excellence has made it a beloved institution in Michigan. Whether you’re a local or a traveler, Zingerman’s offers a taste of Midwest hospitality and flavor.

7. Capriotti’s

Capriotti’s started in Wilmington, DE, and the “Bobbie” sandwich—roasted turkey, stuffing, cranberry sauce—is Thanksgiving on a roll. This unique combination has earned it a devoted following nationwide. The creative menu and quality ingredients make Capriotti’s a standout in the sandwich world. Whether you’re craving holiday flavors or something more traditional, Capriotti’s delivers. It’s a chain that honors its roots while embracing innovation. Each bite of a Capriotti’s sandwich is a reminder of why this Delaware original is so beloved.

8. Primanti Bros.

In Pittsburgh, Primanti Bros. is iconic. Fries and slaw on the sandwich? Believe it. These steel-town eats offer a taste of local flavor in every messy, meaty bite. The bold and hearty combinations have made Primanti Bros. a must-try for anyone visiting the area. It’s a place where tradition and innovation meet, creating unforgettable sandwiches. Whether you’re a local or a visitor, Primanti Bros. delivers a true taste of Pittsburgh. It’s a culinary experience that captures the spirit of the city.

9. Ike’s Love & Sandwiches

Ike’s Love & Sandwiches is known for wild flavor combos and Dutch Crunch bread. This California favorite, with its secret sauces and irreverent vibe, offers a unique sandwich experience. The bold and creative menu reflects the adventurous spirit of the Bay Area and beyond. Customers love the playful names and unexpected ingredients that make each visit exciting. Ike’s is a place where sandwich-making becomes an art form, and every bite is a discovery. It’s a chain that celebrates individuality and flavor.

10. DiBella’s Subs

DiBella’s Subs, with its old-school Italian deli vibes, offers giant portions and freshly baked rolls. This Upstate NY and Midwest favorite is known for its hearty and satisfying options. The commitment to quality and tradition sets DiBella’s apart in the crowded sandwich market. Whether you’re craving a classic Italian sub or something more unique, DiBella’s delivers. It’s a place where customers come for the generous portions and stay for the taste. Each sandwich is a testament to the art of deli craftsmanship.

11. Firehouse Subs

Founded by firefighters, Firehouse Subs delivers regional charm with hot, hearty subs. Known for their generous portions and loads of melted cheese, these sandwiches offer a comforting and satisfying meal. The firefighter theme adds a touch of authenticity and warmth to the dining experience. Customers appreciate the hearty flavors and quality ingredients that make each sub a delight. Whether you’re a fan of traditional flavors or something more adventurous, Firehouse Subs offers something for everyone. It’s a chain that honors its roots while embracing innovation.

12. Lenny’s Grill & Subs

Lenny’s Grill & Subs offers big, messy, flavorful subs in the Southeast. Known for their hearty Philly cheesesteak, these sandwiches deliver a satisfying and indulgent meal. The generous portions and quality ingredients make Lenny’s a favorite among sandwich lovers. Whether you’re craving a classic sub or something more unique, Lenny’s delivers with flavor and flair. The laid-back vibe and commitment to customer satisfaction set Lenny’s apart. It’s a place where sandwich-making becomes an art form, and every bite is a discovery.

13. Cousins Subs

Cousins Subs, with local meats and fresh-baked bread, has earned a loyal Wisconsin following. Known for their pepperoni melts and cheesesteaks, these sandwiches offer a taste of local flavor and tradition. The commitment to quality and freshness sets Cousins Subs apart in the crowded sandwich market. Whether you’re craving a classic sub or something more adventurous, Cousins delivers. It’s a chain that honors its roots while embracing innovation. Each bite of a Cousins sub is a reminder of why this Wisconsin original is so beloved.

14. Potbelly Sandwich Works

Potbelly Sandwich Works, based in Chicago, offers warm, toasted sandwiches with lots of toppings. The Wreck and the Italian are fan favorites, known for their hearty and satisfying flavors. The cozy atmosphere and commitment to quality make Potbelly a standout in the sandwich world. Whether you’re a fan of traditional flavors or something more unique, Potbelly delivers. It’s a place where customers come for the warm, inviting atmosphere and stay for the taste. Each sandwich is a testament to the art of deli craftsmanship.

15. McAlister’s Deli

McAlister’s Deli, started in Mississippi, is known for huge baked potatoes and hearty deli sandwiches. This Southern favorite offers a laid-back vibe and a commitment to quality. The generous portions and diverse menu make McAlister’s a favorite among food lovers. Whether you’re craving a classic deli sandwich or something more unique, McAlister’s delivers. It’s a place where Southern hospitality meets culinary excellence. Each visit to McAlister’s is a reminder of why this Mississippi original is so beloved.

16. Mendocino Farms

Mendocino Farms, with its farm-to-sandwich concept, offers seasonal ingredients and a rotating menu. This California favorite feels more “chef-driven” than most fast-casual sandwich shops. The commitment to quality and creativity sets Mendocino Farms apart. Whether you’re craving a classic sandwich or something more adventurous, Mendocino delivers. The fresh ingredients and innovative combinations make each visit a culinary adventure. It’s a place where customers come for the taste and stay for the quality. Each sandwich is a testament to the art of culinary excellence.

17. Eegee’s

Eegee’s in Tucson, AZ, is half sub shop, half frozen-drink haven. Known for their ranch fries and turkey grinders, they offer a taste of local flavor and fun. The lively atmosphere and commitment to quality make Eegee’s a standout in the sandwich world. Whether you’re craving a classic sub or something more adventurous, Eegee’s delivers. It’s a place where customers come for the fun and stay for the taste. Each visit to Eegee’s is a reminder of why this Tucson original is so beloved.

18. Taylor Gourmet

Taylor Gourmet, inspired by Philadelphia hoagies but with a D.C. edge, offers inventive and flavor-loaded sandwiches. This Washington, D.C. favorite is known for its bold combinations and quality ingredients. The commitment to creativity and authenticity sets Taylor Gourmet apart. Whether you’re craving a classic hoagie or something more unique, Taylor delivers. It’s a place where sandwich-making becomes an art form, and every bite is a discovery. Each visit to Taylor Gourmet is a reminder of why this D.C. original is so beloved.

19. Duckfat Frites Shack

Duckfat Frites Shack in Portland, ME, is not a chain, but if it ever became one—it’d be dangerous. Known for its Belgian-style frites, paninis, and pork belly Cubans, it offers a taste of local flavor and indulgence. The commitment to quality and creativity sets Duckfat apart. Whether you’re craving a classic panini or something more adventurous, Duckfat delivers. It’s a place where culinary excellence meets local charm. Each visit to Duckfat is a reminder of why this Portland original is so beloved.

20. Blimpie

Blimpie, founded in NJ, may not be as flashy as some newer chains, but it remains a nostalgic East Coast sub shop. Known for its solid sandwiches, Blimpie delivers quality and tradition with every bite. The cozy atmosphere and commitment to classic flavors make Blimpie a favorite among sandwich lovers. Whether you’re craving a classic sub or something more unique, Blimpie delivers. It’s a place where customers come for the nostalgia and stay for the taste. Each visit to Blimpie is a reminder of why this NJ original is so beloved.